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In 2005, researchers and the University of California, San Francisco reviewed [http://tobaccocontrol.bmj.com/cgi/content/abstract/14/6/396 unpublished in vivo research on secondhand cigarette smoke performed by scientists] at the [[Philip Morris]] during the 1980s at its overseas biological lab Institut für Biologische Forschung, or [[INBIFO]]. Between 1981 and 1989 PM performed at least 115 separate studies at INBIFO on the toxicity of secondhand tobacco smoke. The existence of these studies on secondhand smoke was completely unknown until the tobacco industry's internal documents were made public on the Internet in 1998. PM's studies revealed that inhaled fresh secondhand smoke is approximately four times more toxic per gram in its total particulate matter than mainstream cigarette smoke (the smoke the smoker himself inhales). The condensate ("tar") derived from secondhand smoke is approximately three times more toxic per gram and two to six times more tumorigenic per gram than the condensate produced by mainstream smoke when applied to skin. Philip Morris never revealed the results of these studies to the public or any government.

Secondhand smoke is more chemically potent that what the smoker himself inhales.